BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN BEGIN:VEVENT UID:539@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20240912T120000 DTEND;TZID=Europe/Helsinki:20240912T130000 DTSTAMP:20240612T120624Z URL:https://biocityturku.fi/events/frontiers-of-science-prof-ellen-rothenb erg/ SUMMARY:Frontiers of Science: Prof. Ellen Rothenberg DESCRIPTION:September 12th at 12:00\nOn-site event\nPresidentti auditorium\ , BioCity\n\nProf. Ellen Rothenberg\, California Institute of Technology\, USA\nEpigenomic and gene regulatory network mechanisms controlling the dy namics of early T cell lineage commitment\nHost: Riitta Lahesmaa (rilahes@ utu.fi)\n\nCoffee and sandwich at 11:45\, first come first served!\n\n&nbs p\;\n\nSix PhD researchers and early-career postdocs are welcome to have a lunch in and discuss with Prof. Rothenberg after the seminar. This is a g reat possibility to learn hosting skills in friendly environment and creat e connections for future. Everyone is welcome to join\, BioCity Turku will offer the lunch.\n\nIf you got interested\, please send an email to bioci tyturku@bioscience.fi\n\n \;\n\nThe Rothenberg group studies the molec ular mechanisms that are responsible for developmental lineage choice as h ematopoietic stem cells differentiate into T lymphocytes. This is a comple x process in which stem-cell multipotentiality is lost in steps that actua lly overlap with the initiation of T-cell specific differentiation events. Thus\, it offers unique insights into the nature of "stem-ness" and the d istinction between activation of a development program and irreversible co mmitment to that program. The approaches used in the lab are a combination of in vitro developmental biology\, high-resolution characterization of i ndividual cell developmental states\, and molecular genetics of gene regul ation. The Rothenberg group focuses on identifying the transcription facto rs and signaling events that induce T-lineage gene expression in an uncomm itted precursor and determine also how they work to force the cell to reli nquish other developmental options. Kinetic dissection of this complex pro cess using in vitro differentiation systems and retroviral perturbation ma ke it possible to solve the roles of individual regulatory molecules in su ccessive\, highly-defined developmental contexts.\n\n \;\n\nSelected p ublications\n\nShin B\, Zhou W\, Wang J\, Gao F\, Rothenberg EV. 2023. Run x factors launch T cell and innate lymphoid programs via direct and gene n etwork-based mechanisms. Nat Immunol. 2023 Sep\;24(9):1458-1472. doi: 10.1 038/s41590-023-01585-z\n\nRothenberg EV. 2023. The β-selection step shape s T-cell identity. Nature. 2023 Jan\;613(7944):440-442. doi: 10.1038/d4158 6-023-00025-0\n\nShin B\, Hosokawa H\, Romero-Wolf M\, Zhou W\, Masuhara K \, Tobin VR\, Levanon D\, Groner Y\, Rothenberg EV. 2021. Runx1 and Runx3 drive progenitor to T-lineage transcriptome conversion in mouse T cell com mitment via dynamic genomic site switching. Proc Natl Acad Sci U S A. 2021 Jan 26\;118(4):e2019655118. doi: 10.1073/pnas.2019655118\n\n \n\nGeneral information\n\n You can download and save all the autumn 2024 FoS-semina rs to your calendar from here: https://seafile.utu.fi/d/44a70f80ac1e46a9ad 0a/\n Registration is not needed\, participation list is circulated in th e audience\n If you are a student and later wish to get a certificate of attendance from the Frontier of Science seminars\, print out the seminar d iary and after the seminar ask the BioCity coordinator to sign it https:// seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Please note that any audio or vi deo recording of the seminars is strictly forbidden.\n Autumn 2024 image credits to Mia Åstrand: Details of the Bacteroides fragilis VgrG protein (PDB ID: 8GRA). Image created in the PyMOL Molecular Graphics System\, Ver sion 2.5 Schrödinger\, LLC.\n\n \;\n\n \;\n\n \; ATTACH;FMTTYPE=image/jpeg:https://biocityturku.fi/wp-content/uploads/rothe nberg-400-1.jpg CATEGORIES:Frontiers of Science END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20240331T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR