BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN BEGIN:VEVENT UID:636@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20241205T120000 DTEND;TZID=Europe/Helsinki:20241205T130000 DTSTAMP:20241001T073949Z URL:https://biocityturku.fi/events/frontiers-of-science-prof-bernhard-kust er/ SUMMARY:Frontiers of Science: Prof. Bernhard Küster DESCRIPTION:December 5th at 12:00\nOnsite event\nin Presidentti auditorium\ , BioCity\nAutumn 2024 Seminars\n\nProf. Bernhard Küster\, Technical Univ ersity of Munich\, Germany\nCancer patient and drug proteome profiling enh ance treatment recommendations in molecular tumor boards\nHost: Jukka West ermarck (jukka.westermarck@utu.fi)\n\nCoffee and sandwich at 11:45\, first come first served!\n\n \;\n\nSix PhD researchers and early-career pos tdocs are welcome to have a lunch and discuss with Prof. Küster after the seminar. This is a great possibility to learn hosting skills in a friendl y environment and create connections for future. Everyone is welcome to jo in\, BioCity Turku will offer the lunch.\n\nIf you got interested\, please send an email to biocityturku@bioscience.fi\n\n \;\n\nProf. Küster l eads Proteomics and Bioanalytics group at the Technical University of Muni ch\, which comprises an international research team with a focus on proteo mics and chemical biology. Most of their research builds on the powerful c ombination of cell biology\, chemistry\, biochemistry\, mass spectrometry and bioinformatics. The group develops novel analytical methods for quanti tative proteome research notably for high throughput applications and the analysis of post translational protein modifications (PTMs). In their chem ical biology efforts\, they elucidate the selectivity of drug-target inter actions on a proteome-wide scale\, investigate the cellular mechanisms by which drugs exert their function and identify mechanisms of cancer therapy resistance. In addition\, the group investigates phosphoproteomic signali ng events as biomarkers for patient stratification\, as well as indicators of drug effectiveness and treatment response.\n\n \;\n\nSelected publ ications\n\nChang YC\, Gnann C\, Steimbach RR\, Bayer FP\, Lechner S\, Sak hteman A\, Abele M\, Zecha J\, Trendel J\, The M\, Lundberg E\, Miller AK\ , Kuster B. 2024. Decrypting lysine deacetylase inhibitor action and prote in modifications by dose-resolved proteomics. Cell Rep. 43(6):114272. doi: 10.1016/j.celrep.2024.114272\n\nEckert S\, Berner N\, Kramer K\, Schneide r A\, Müller J\, Lechner S\, Brajkovic S\, Sakhteman A\, Graetz C\, Fackl er J\, Dudek M\, Pfaffl MW\, Knolle P\, Wilhelm S\, Kuster B. 2024. Decryp ting the molecular basis of cellular drug phenotypes by dose-resolved expr ession proteomics. Nat Biotechnol. doi: 10.1038/s41587-024-02218-y\n\nRein ecke M\, Brear P\, Vornholz L\, Berger BT\, Seefried F\, Wilhelm S\, Samar as P\, Gyenis L\, Litchfield DW\, Médard G\, Müller S\, Ruland J\, Hyvö nen M\, Wilhelm M\, Kuster B. 2024. Chemical proteomics reveals the target landscape of 1\,000 kinase inhibitors. Nat Chem Biol. 20(5):577-585. doi: 10.1038/s41589-023-01459-3.\n\nLechner S\, Steimbach RR\, Wang L\, Deline ML\, Chang YC\, Fromme T\, Klingenspor M\, Matthias P\, Miller AK\, Méda rd G\, Kuster B. 2026. Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid. Nat Commun. 14(1):3548. doi: 10.1038/s41467-023-39151-8.\n\n \;\n\nGeneral information\n\n You can download and save all the autumn 2024 FoS-seminars to your calendar from here: https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Registration is no t needed\, participation list is circulated in the audience\n If you are a student and later wish to get a certificate of attendance from the Front ier of Science seminars\, print out the seminar diary and after the semina r ask the BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80 ac1e46a9ad0a/\n Please note that any audio or video recording of the semi nars is strictly forbidden.\n Autumn 2024 image credits to Mia Åstrand: Details of the Bacteroides fragilis VgrG protein (PDB ID: 8GRA). Image cre ated in the PyMOL Molecular Graphics System\, Version 2.5 Schrödinger\, L LC.\n ATTACH;FMTTYPE=image/jpeg:https://biocityturku.fi/wp-content/uploads/kuste r-400.jpg CATEGORIES:Frontiers of Science END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20241027T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR