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UID:435@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20190207T120000
DTEND;TZID=Europe/Helsinki:20190207T130000
DTSTAMP:20231013T063132Z
URL:https://biocityturku.fi/events/frontiers-of-science-novel-roles-of-roc
 k-myosin-ii-in-cancer/
SUMMARY:Frontiers of Science: Novel roles of ROCK-Myosin II in cancer
DESCRIPTION:Professor Victoria Sanz-Moreno\, Queen Mary University of Londo
 n\, UK\n\nHost: Johanna Ivaska (johanna.ivaska@utu.fi)\n\nProf Sanz-Moreno
  is a group leader at the Barts Cancer Institute in London (UK). She recei
 ved her PhD in chemical sciences at the University of Cantabria. After a s
 hort postdoc in the same lab\, she moved to the Institute of Cancer Resear
 ch in London as a CRUK and Marie Curie Intra-European Fellow with Chris Ma
 rshall. In 2011\, she established her own lab at King’s College London (
 Randall Centre for cell and molecular biophysics). In 2017\, she was award
 ed the BSCB Women in Cell Biology Early Career Award Medal before joining 
 the Barts Cancer Institute in 2018.\n\nThe Sanz-Moreno lab works on unders
 tanding how the cytoskeleton and Rho GTPase signalling in cancer cells pro
 mote tumour growth and dissemination by modulating transcription factors. 
 Their ultimate goal is to establish whether manipulating the cancer cell c
 ytoskeleton will lead to improved efficacy of current therapeutic approach
 es in patients via transcriptional reprogramming. The lab combines 'OMICs'
 \, state of the art microscopy in 3D matrices\, molecular biology\, animal
  models and digital pathology in patient tissues to identify molecular det
 erminants driven by Rho GTPase signalling that correlate with cancer progr
 ession and metastatic potential.\n\nLinks:\nLab website: http://www.sanz-m
 oreno-lab.co.uk/\nJournal of Cell Biology interview with Prof Sanz-Moreno:
  People and ideas (2018)\n\nSelected publications:\nMuliaditan T\, Okesola
  M\, Caron J\, Georgouli M\, Gordon P\, Lall S\, Kuzeva D\, Pedro L\, Shie
 lds J\, Gillettn C\, Diebold S\, Sanz-Moreno V\, Ng T\, Hoste E\, Arnold J
  (2018) Tumour-associated macrophages exploit an innate wound healing resp
 onse to facilitate metastasis. Nat Comm. 9(1):2951.\n\nPandya P\, Orgaz JL
  and Sanz-Moreno V (2017) Actomyosin contractility in collective migration
 : May the force be with you. Special issue on "Cell Dynamics” Curr Opin 
 Cell Biol\, 48:87–96\n\nOrgaz JL\, Pandya P and Sanz-Moreno V (2017) Mod
 es of invasion during tumour dissemination. Molecular Oncology 11(1):5-27.
 \n\nKrupina K\, Kleiss C\, Rodriguez-Hernandez I\, Sanz-Moreno V and Sumar
 a I (2017). UBASH3B-mediated silencing of the mitotic checkpoint: therapeu
 tic perspectives in cancer cells. Molecular &amp\; Cellular Oncology\, 10.
 1080/23723556.2016.1271494.\n\nCrosas E\, Bertran E\, Cantelli G\, Herraiz
  C\, Rodriguez-Hernandez I\, Fabra A\, Sanz-Moreno V* and Fabregat I* (201
 7) *co-corresponding senior authors. NADPH oxidase NOX4 represses epitheli
 al to amoeboid transition and efficient tumour dissemination. Oncogene 36(
 21):3002-3014\n\nHerraiz C\, Calvo F\, Pandya P\, Cantelli G\, Rodriguez-H
 ernandez I\, Orgaz JL\, Kang N\, Chu T\, Sahai E\, Sanz-Moreno V. Reactiva
 tion of p53 by a cytoskeletal sensor to control the balance between DNA da
 mage and tumour dissemination. J Natl Cancer Inst. (2016) 108(1). PMID: 
 26464464\n\nCantelli G\, Orgaz JL\, Rodriguez-Hernandez I\, Karagiannis P\
 , Maiques O\, Matias-Guiu X\, Nestle FO\, Marti RM\, Karagiannis SN\, Sanz
 -Moreno V. TGFb-induced transcription sustains amoeboid melanoma migratio
 n and dissemination. Curr Biol (2015) 16\;25(22):2899-914. PMID: 2652636
 9\n\nOrgaz JL\, Pandya P\, Dalmeida R\, Karagiannis P\, Sanchez-Laorden B\
 , Viros A\, Albrengues J\, Nestle FO\, Ridley AJ\, Gaggioli C\, Marais R\,
  Karagiannis SN\, Sanz-Moreno V. Diverse Matrix metalloproteinase functio
 ns regulate cancer amoeboid migration. Nat Comm (2014) 5:4255. PMID: 24
 963846\n\nSanz-Moreno V*\, Gaggioli\, C*\, Yeo M Albrengues J. Wallberg F\
 , Viros A \, Hooper S\, Mitter R\, Feral C\, Cook M\; Larkin J \, Marais R
  \, Meneguzzi G\, Sahai E\, Marshall CJ. ROCK and JAK1 signalling cooperat
 e to control actomyosin contractility in tumour cells and stroma. Cancer C
 ell (2011) 20\, 229-45. PMID: 21840487 * equal contribution
CATEGORIES:BiocityTurku events
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