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UID:439@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20190509T120000
DTEND;TZID=Europe/Helsinki:20190509T130000
DTSTAMP:20231013T063133Z
URL:https://biocityturku.fi/events/frontiers-of-science-membrane-dynamics-
 in-macroautophagy-dissecting-intracellular-self-eating-with-3d-electron-mi
 croscopy/
SUMMARY:Frontiers of Science: Membrane dynamics in macroautophagy: dissecti
 ng intracellular self-eating with 3D electron microscopy
DESCRIPTION:Prof. Eeva-Liisa Eskelinen\, University of Turku\n\nHost: Jyrki
  Heino (jyheino@utu.fi)\n\n&nbsp\;\n\nEeva-Liisa Eskelinen is a Professor 
 in medical cell biology\, Institute of Biomedicine\, University of Turku (
 since November 2017)\n\nAutophgy is a lysosomal recycling pathway for cyto
 plasmic material and organelles\, which maintains cellular homeostasis. Es
 kelinen group investigates membrane dynamics during autophagy in mammalian
  cells. In order to clarify the elusive process of autophagosome formation
 \, they have used three-dimensional electron microscopy to demonstrate con
 nections between nascent autophagosomes and other membrane-bound organelle
 s. The group has also studied the roles of small GTPases in autophagy\, an
 d reported that RAB24 plays a role in autolysosomes\, the last intermediat
 e on the autophagy pathway.\n\nSelected publications\n\nEskelinen E-L: Aut
 ophagy: supporting cellular and organismal homeostasis by self-eating. Int
  J Biochem Cell Biol 2019\, 111:1-10. DOI:https://doi.org/10.1016/j.biocel
 .2019.03.010\n\nBoland B\, Yu WH\, Corti O\, Mollereau B\, Henriques A\, B
 ezard E\, Pastores GM\, Rubinsztein DC\, Nixon RA\, Duchen MR\, Mallucci G
 R\, Kroemer G\, Levine B\, Eskelinen E-L\, Mochel F\, Spedding M\, Louis C
 \, Martin OR\, Millan MJ: Promoting the clearance of neurotoxic proteins i
 n neurodegenerative disorders of aging. Nat Rev Drug Disc 2018\, 17:660-68
 8. DOI:10.1038/nrd.2018.109\n\nSyrjä P\, Anwar T\, Jokinen TS\, Kyöstil
 ä K\, Hultin-Jäderlund K\, Cozzi F\, Rohdin C\, Hahn K\, Wohlsein P\, Ba
 umgärtner W\, Henke D\, Oevermann A\, Sukura A\, Leeb T\, Lohi H\, Eskeli
 nen E-L: Basal Autophagy is altered in Lagotto Romagnolo Dogs with an ATG4
 D mutation. Veterinary Pathology 2017\, 54:953-963. DOI: 10.1177/030098581
 7712793\n\nYlä-Anttila P\, Mikkonen E\, Happonen KE\, Holland P\, Ueno T\
 , Simonsen A\, Eskelinen E-L: RAB24 facilitates clearance of autophagic co
 mpartments during basal conditions. Autophagy 2015\, 11:1833-48. DOI: 10.1
 080/15548627.2015.1086522\n\nBiazik J\, Ylä-Anttila P\, Vihinen H\, Jokit
 alo E and Eskelinen E-L: Ultrastructural relationship of the phagophore wi
 th surrounding organelles. Autophagy 2015\, 11:439-451. DOI:10.1080/155486
 27.2015.1017178\n\n&nbsp\;
CATEGORIES:BiocityTurku events
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TZID:Europe/Helsinki
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DTSTART:20190331T040000
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