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UID:449@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20181220T120000
DTEND;TZID=Europe/Helsinki:20181220T130000
DTSTAMP:20231013T063137Z
URL:https://biocityturku.fi/events/frontiers-of-science-imaging-cell-migra
 tion-in-gut-homeostasis-and-cancer/
SUMMARY:Frontiers of Science: Imaging cell migration in gut homeostasis and
  cancer
DESCRIPTION:Dr. Danijela Vignjevic\, Institute Curie\, Paris\, France\n\nHo
 st: Johanna Ivaska (johanna.ivaska@utu.fi)\n\nDr Vignjevic leads the Cell 
 Migration and Invasion group in the INSERM/Institut Curie. She obtained he
 r PhD degree in 2003 in Gary Borisy's lab at the Northwestern University M
 edical School (Chicago\, US). Following a very successful postdoctoral fel
 lowship in Daniel Louvard’s lab at Institut Curie (Paris\, FR)\, she the
 n started her own independent research group at the same institute.\n\nThe
  broad objective of Dr Vignjevic’s research is to understand how epithel
 ial cells interact with their microenvironment during migration\, focusing
  on the mechanism of cell migration and the role of the actin cytoskeleton
  in this process. Danijela’s group uses the gut as a model system to und
 erstand cell migration in homeostasis\, wound healing and cancer invasion.
  Their research strategy combines molecular and cell biology techniques wi
 th live-cell imaging. In particular\, her group uses 2D and 3D in vitro ce
 ll cultures\, ex vivo tissue cultures\, and different transgenic mouse mod
 els to study cell migration in detail.\n\nFor more information and for som
 e beautiful examples of the group’s imaging capabilities\, please visit 
 their website.\n\nSelected (recent) publications:\nBarbazán J\, Vignjevic
  DM (2018) Cancer associated fibroblasts: is the force the path to the dar
 k side? Curr Opin Cell Biol\, 56:71-79\n\nBaschieri F\, Dayot S\, Elkhatib
  N\, Ly N\, Capmany A\, Schauer K\, Betz T\, Vignjevic DM\, Poincloux R\, 
 Montagnac G (2018) Frustrated endocytosis controls contractility-independe
 nt mechanotransduction at clathrin-coated structures. Nat Commun. 9(1):382
 5\n\nClark AG\, Simon A\, Aizel K\, Bibette J\, Bremond N\, Vignjevic DM (
 2018). 3D cell migration in the presence of chemical gradients using micro
 fluidics. Methods Cell Biol\, 147:133-147\n\nAlexandros Glentis\, Philipp 
 Oertle\, Pascale Mariani\, Aleksandra Chikina\, Fatima El Marjou\, Youmna 
 Attieh\, Francois Zaccarini\, Marick Lae\, Damarys Loew\, Florent Dingli\,
  Philemon Sirven\, Marie Schoumacher\, Basile G Gurchenkov\, Marija Plodin
 ec\, Danijela Matic Vignjevic (2017) Cancer-associated fibroblasts induce 
 metalloprotease-independent cancer cell invasion of the basement membrane.
  Nature communications: 924\n\nKoceila Aizel\, Andrew G Clark\, Anthony Si
 mon\, Sara Geraldo\, Anette Funfak\, Pablo Vargas\, Jérôme Bibette\, Dan
 ijela Matic Vignjevic\, Nicolas Bremond (2017) A tuneable microfluidic sys
 tem for long duration chemotaxis experiments in a 3D collagen matrix. Lab 
 on a chip: DOI: 10.1039/c7lc00649g\n\nYoumna Attieh\, Andrew G Clark\, Car
 ina Grass\, Sophie Richon\, Marc Pocard\, Pascale Mariani\, Nadia Elkhatib
 \, Timo Betz\, Basile Gurchenkov\, Danijela Matic Vignjevic (2017) Cancer-
 associated fibroblasts lead tumor invasion through integrin-β3-dependent 
 fibronectin assembly. The Journal of Cell Biology\, 216(11):3509-3520\n\nJ
 orge Barbazan\, Lorena Alonso-Alconada\, Nadia Elkhatib\, Sara Geraldo\, V
 asily Gurchenkov\, Alexandros Glentis\, Guillaume van Niel\, Roberta Palmu
 lli\, Beatriz Fernandez\, Patricia Viaño\, Tomás García-Caballero\, Raf
 ael López López\, Miguel Abal\, Danijela Matic Vignjevic (2017) Liver me
 tastasis is facilitated by the adherence of circulating tumor cells to vas
 cular fibronectin deposits. Cancer Research\, 77(13):3431-3441\n\nYoumna A
 ttieh\, Danijela Matic Vignjevic (2016) The hallmarks of CAFs in cancer in
 vasion. European Journal of Cell Biology\, 493-502\n\nAndrew G Clark\, Dan
 ijela Matic Vignjevic (2015) Modes of cancer cell invasion and the role of
  the microenvironment. Current Opinion in Cell Biology\, 13-22
CATEGORIES:BiocityTurku events
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