BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN BEGIN:VEVENT UID:537@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20240307T120000 DTEND;TZID=Europe/Helsinki:20240307T130000 DTSTAMP:20231219T183221Z URL:https://biocityturku.fi/events/frontiers-of-science-assoc-prof-sirio-d upont/ SUMMARY:Frontiers of Science: Assoc. Prof. Sirio Dupont DESCRIPTION:March 7th at 12:00\nOn-site event\nPresidentti auditorium\, Bio City\nSpring 2024 program\n\nAssoc. Prof. Sirio Dupont\, University of Pad ova\, Italy\nMitochondrial fission coordinates the transcriptional and met abolic response to forces\nHost: Johanna Ivaska (johanna.ivaska@utu.fi)\n\ nCoffee and sandwich at 11:45\, first come first served!\n\n \;\n\nSix PhD researchers and early-career postdocs are welcome to have a lunch in restaurant Mauno and discuss with Assoc. Prof. Dupont after the seminar. T his is a great possibility to learn hosting skills in friendly environment and create connections for future. Everyone is welcome to join\, BioCity Turku will offer the lunch.\n\nIf you got interested\, please send an emai l to biocityturku@bioscience.fi\n\n \;\n\nDupont lab is interested in understanding how the mechanical properties of the extracellular matrix (E CM) regulate signaling pathways\, gene transcription and other cellular pr ocesses\, and how this is relevant for cell behavior\, tissue homeostasis and disease. Their goal is to identify novel general principles in vitro\, and to push their validation in vivo with the development of new animal m odels to study mechano-signaling in tissues. Dupont lab uses a multidiscip linary approach that includes custom-built compliant cell culture substrat a\, ECM micropatterning\, cell micromanipulations\, optical microscopy\, m olecular and cell biology techniques\, transcriptional and bioinformatic a nalyses\, proteomics\, metabolomics\, CRISPR/Cas9 modified cell lines\, an d genetically-modified mice\, also thanks to multiple collaborations with colleagues in Italy and abroad. Dupont lab has identified YAP/TAZ transcri ptional coactivators as readers of ECM mechanical cues and mediators of th eir effects on cancer cell proliferation and mesenchymal stem cell differe ntiation\, and are now developing genetic tools to study the relevance of F-actin remodeling as regulator of YAP/TAZ activity in vivo. Moreover\, th ey got recently interested in understanding how mechanical cues\, YAP/TAZ and metabolism are reciprocally regulated.\n\n \;\n\nSelected publicat ions\n\nDupont S\, Wickström SA. 2022. Mechanical regulation of chromatin and transcription. Nat Rev Genet. 2022 Oct\;23(10):624-643. doi: 10.1038/ s41576-022-00493-6\n\nRomani P\, Nirchio N\, Arboit M\, Barbieri V\, Tosi A\, Michielin F\, Shibuya S\, Benoist T\, Wu D\, Hindmarch CCT\, Giomo M\, Urciuolo A\, Giamogante F\, Roveri A\, Chakravarty P\, Montagner M\, Cal ì T\, Elvassore N\, Archer SL\, De Coppi P\, Rosato A\, Martello G\, Dupo nt S. 2022. Mitochondrial fission links ECM mechanotransduction to metabol ic redox homeostasis and metastatic chemotherapy resistance. Nat Cell Biol . 2022 Feb\;24(2):168-180. doi: 10.1038/s41556-022-00843-wPMID: 35165418\n \nRomani P\, Brian I\, Santinon G\, Pocaterra A\, Audano M\, Pedretti S\, Mathieu S\, Forcato M\, Bicciato S\, Manneville JB\, Mitro N\, Dupont S. 2 019. Extracellular matrix mechanical cues regulate lipid metabolism throug h Lipin-1 and SREBP. Nat Cell Biol. 2019 Mar\;21(3):338-347. doi: 10.1038/ s41556-018-0270-5\n\n \;\n\nGeneral information\n\n You can download and save all the spring 2024 FoS-seminars to your calendar from here: http s://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Registration is not needed\, participation list is circulated in the audience\n If you are a student and later wish to get a certificate of attendance from the Frontier of Sci ence seminars\, print out the seminar diary and after the seminar ask the BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad 0a/\n Please note that any audio or video recording of the seminars is st rictly forbidden.\n Spring 2024 FoS image credits to Jenny Pessa: Transfo rmed human breast epithelial HS578T cells (flattened)\, labelled with comm ercial fluorescent antibodies. Image acquired on 3i CSU-W1 Spinning disk w ith 40x objective.\n\n \;\n\n \;\n\n \; ATTACH;FMTTYPE=image/jpeg:https://biocityturku.fi/wp-content/uploads/dupon t-400.jpg CATEGORIES:Frontiers of Science END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20231029T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR