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UID:452@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20180906T120000
DTEND;TZID=Europe/Helsinki:20180906T130000
DTSTAMP:20231013T063209Z
URL:https://biocityturku.fi/events/fos-exposing-molecular-transformers-in-
 organelles-at-atomic-resolution-by-cryo-em/
SUMMARY:Frontiers of Science: Exposing molecular transformers in organelles
  at atomic resolution by cryo-EM
DESCRIPTION:Dr. Alexey Amunts\, Stockholm University\, Sweden\n\nHost: Paul
 a Mulo (pmulo@utu.fi)\n\n \n\nDr Alexey Amunts has focused on the fundame
 ntal question of how proteins are synthesized\, folded and assembled into 
 functional multicomponent membrane complexes that drive the cellular energ
 y production by applying cryo-EM visualisation of bioenergetic complexes.\
 n\nThe research group of Dr. Amunts has determined cryo-EM structures of t
 he human mitoribosome with mRNA\, tRNAs and translation activators in 8 di
 fferent functional states\, and they have revealed unique mechanisms of mR
 NA binding\, tRNA translocation and assembly regulation. They have also de
 termined structures of the chlororibosome with translation factors that re
 vealed divarication of the exit tunnel and experimental evidence for conve
 rgent evolution of ribosomes from chloroplasts and mitochondria. These stu
 dies showed that protein synthesis machineries in organelles have adopted 
 intricate compositions and unique tasks\, adding incredible complexity to 
 the records. The achieved understanding of the architecture of these speci
 alized systems provides now a framework to study even more sophisticated q
 uestions regarding the assembly and evolution mechanisms of the critical b
 ioenergetic membranes that fuel life.\n\n&nbsp\;\n\nSelected publications\
 n\nBoerema AP\, Aibara S\, Paul B\, Tobiasson V\, Kimanius D\, Forsberg BO
 \, Wallden K\, Lindahl E\, Amunts A. (2018) Structure of the chloroplast r
 ibosome with chl-RRF and hibernation-promoting factor. Nat Plants. 4: 212-
 217.\n\nRorbach J\, Aibara S\, Amunts A. (2018) Ribosome origami. Nat Stru
 ct Mol Biol. 24: 879-881\n\nMatzov D\, Aibara S\, Basu A\, Zimmerman E\, B
 ashan A\, Yap MF\, Amunts A\, Yonath AE. (2017) The cryo-EM structure of h
 ibernating 100S ribosome dimer from pathogenic Staphylococcus aureus. Nat 
 Commun. 8 :723\n\nBrown A\, Rathore S\, Kimanius D\, Aibara S\, Bai XC\, R
 orbach J\, Amunts A\, Ramakrishnan V. (2017) Structures of the human mitoc
 hondrial ribosome in native states of assembly. Nat Struct Mol Biol. 24: 8
 66-869.\n\nDesai N\, Brown A\, Amunts A\, Ramakrishnan V. (2017) The struc
 ture of the yeast mitochondrial ribosome. Science. 355: 528-531.\n\nOtt M\
 , Amunts A\, Brown A. (2016) Organization and Regulation of Mitochondrial 
 Protein Synthesis. Annu Rev Biochem. 85: 77-101.\n\nDe Silva D\, Tu YT\, A
 munts A\, Fontanesi F\, Barrientos A. (2015) Mitochondrial ribosome assemb
 ly in health and disease. Cell Cycle. 14: 2226-50.\n\nAmunts A\, Brown A\,
  Toots J\, Scheres SHW\, Ramakrishnan V. (2015) Ribosome. The structure of
  the human mitochondrial ribosome. Science. 348: 95-98.\n\nAmunts A\, Fied
 orczuk K\, Truong TT\, Chandler J\, Peter Greenberg E\, Ramakrishnan V. (2
 015) Bactobolin A binds to a site on the 70S ribosome distinct from previo
 usly seen antibiotics. J Mol Biol. 427:753-5.\n\nBrown A\, Amunts A\, Bai 
 XC\, Sugimoto Y\, Edwards PC\, Murshudov G\, Scheres SHW\, Ramakrishnan V.
  (2014) Structure of the large ribosomal subunit from human mitochondria. 
 Science. 346: 718-722.\n\n&nbsp\;
CATEGORIES:BiocityTurku events
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DTSTART:20180325T040000
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