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UID:408@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20191003T120000
DTEND;TZID=Europe/Helsinki:20191003T130000
DTSTAMP:20231013T062913Z
URL:https://biocityturku.fi/events/frontiers-of-science-signatures-of-muta
 tion-in-squamous-cell-carcinoma/
SUMMARY:Frontiers of science: Signatures of Mutation in Squamous Cell Carci
 noma
DESCRIPTION:Dr. Andrew South\, Jefferson College of Life Sciences\, Philade
 lphia\, USA\nSignatures of Mutation in Squamous Cell Carcinoma\n\nHost: Ve
 li-Matti Kähäri (velkah@utu.fi )\n\nAndrew South is a genetics graduate 
 from the University of Leeds\, He obtained his Ph.D. from the University o
 f London in 1999 whilst working on the human genome project with Dean Nize
 tic. From 1999‐2002 he was a postdoctoral research fellow at St John’s
  Institute of Dermatology\, St Thomas’ Hospital\, London\, with John McG
 rath. He then worked as a research associate with Ian Hart and subsequentl
 y as lecturer in Irene Leigh’s department at Bart’s and the London fro
 m 2002 to 2007. From 2007-2014\, he was a lecturer\, then senior lecturer 
 at the University of Dundee. Currently he is an Associate Professor in the
  Department of Dermatology and Cutaneous Biology at Thomas Jefferson Unive
 rsity\, Philadelphia. He has authored over 90 peer reviewed articles on th
 e subjects of genetic skin disease and squamous cell carcinoma. His resear
 ch focuses on dissecting basic mechanisms implicated in the underlying pat
 hogenesis of skin disorders such as recessive dystrophic epidermolysis bul
 losa and cutaneous squamous cell carcinoma (SCC). His recent studies deal 
 with mutational burden and TGF-β signaling in the progression of cSCC\, a
 nd with development of new therapeutic approaches for cSCC.\n\nSelected pu
 blications\nCho RJ\, Alexandrov LB\, den Breems NY\, Atanasova VS\, Farshc
 hian M\, Purdom E\, Nguyen TN\, Coarfa C\, Rajapakshe K\, Prisco M\, Sahu 
 J\, Tassone P\, Greenawalt EJ\, Collisson EA\, Wu W\, Yao H\, Su X\, Grube
 r C\, Piñón Hofbauer J\, Hashmi R\, Fuentes I\, Benz SC\, Golovato J\, E
 hli EA\, Davis CM\, Davies GE\, Covington KR\, Murrell DF\, Salas-Alanis J
 C\, Palisson F\, Bruckner AL\, Robinson W\, Has C\, Bruckner-Tuderman L\, 
 Titeux M\, Jonkman MF\, Rashidghamat E\, Lwin S\, Mellerio J\, McGrath JA\
 , Bauer JW\, Hovnanian A\, Tsai KY\, South AP. APOBEC mutation drives earl
 y-onset squamous cell carcinomas in recessive dystrophic epidermolysis bul
 losa. Sci Trans Med. 10(455). eaas9668. doi: 10.1126/scitranslmed.aas9668.
  PMID: 30135250\n\nAtanasova VS\, Pourreyron C\, Farshchian M\, Lawler M\,
  Brown IV CA\, Watt SA\, Wright S\, Warkala M\, Guttmann-Gruber C\, Piñó
 n Hofbauer J\, Fuentes I\, Prisco M\, Rashidghamat E\, Has C\, Salas-Alani
 s JC\, Palisson F\, Hovnanian A\, McGrath JA\, Mellerio JE\, Bauer JW\, So
 uth AP. Identification of rigosertib for the treatment of recessive dystro
 phic epidermolysis bullosa-associated squamous cell carcinoma. Clin Cancer
  Res March 7 2019 DOI:10.1158/1078-0432.CCR-18-2661. PMID: 30846478\n\nInm
 an GJ\, Wang J\, Nagano A\, Alexandrov LB\, Purdie KJ\, Sherwood V\, Taylo
 r R\, South AP\, Stratton M\, Chelala C\, Harwood CA\, Proby CM\, Leigh IM
 . The genomic landscape of cutaneous squamous cell carcinoma from immunosu
 ppressed and immunocompetent patients reveals common drivers and a novel m
 utational signature associated with chronic azathioprine exposure. Nat. Co
 mmun. 2018 9(1):3667. doi: 10.1038/s41467-018-06027-1. PMID: 30202019\n\nS
 outh AP\, Purdie KJ\, Watt SA\, Haldenby S\, den Breems N\, Dimon M\, Arro
 n ST\, Kluk MJ\, Aster JC\, McHugh A\, Xue DJ\, Dayal JHS\, Robinson KS\, 
 Rizvi SMH\, Proby CM\, Harwood CA\, Leigh IM. NOTCH1 mutations occur early
  during cutaneous squamous cell carcinogenesis. J Invest Dermatol. 2014 13
 4(10): 2630-8.
CATEGORIES:Frontiers of Science
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