BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN BEGIN:VEVENT UID:713@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20250123T120000 DTEND;TZID=Europe/Helsinki:20250123T130000 DTSTAMP:20250114T094733Z URL:https://biocityturku.fi/events/findos-and-mirp-seminar-prof-gilad-bach rach/ SUMMARY:FINDOS and MIRP Seminar: Prof. Gilad Bachrach DESCRIPTION:23rd January at 12:00-13:oo\nOnsite event\nin Lauren 2\, Medisi ina D\n\nProf. Gilad Bachrach\, The BacteriOncology Lab\, The Hebrew Unive rsity-Hadassah School of Dental Medicine\nTumor acceleration by Fusobacter ium nucleatum: mechanisms and opportunities\n\nHost: Prof. Ulvi Gürsoy\n\ nThe seminar is open for everyone and no registration is needed. Welcome e veryone!\n\n \;\n\nDr. Bachrach is a microbiologist at the Institute o f Dental Sciences of the Hebrew University-Hadassah School of Dental Medic ine in Jerusalem. He is investigating the involvement of fusobacteria in t umor acceleration and the possible use of bacteria for cancer therapy. Dr. Bachrach received his BSc\, MSc and PhD from the Hebrew University in Jer usalem. He was a post doctorate fellow at the National Institute of Medica l Research in Mill Hill London where he investigated molecular mechanisms involved in the virulence of Mycobacterium tuberculosis and in the Nationa l Institutes of Health (USA) where his interest in fusobacteria begun.  h ttps://giladba.wixsite.com/laboratory\n\nF. nucleatum is an oral anaerobic pathobiont found to accumulate in human colorectal\, pancreatic\, esophag eal and breast cancers. In these cancers\, fusobacterial overabundance is correlated with poor treatment outcome. The fusobacterial Fap2 outer-membr ane protein was found to mediate specific colonization of high Gal-GalNAc displaying tumors. Once in the tumor\, fusobacterial- induced suppression of anti-tumor immunity appears to play a key role in tumor acceleration by F. nucleatum. Can F. nucleatum be used to target tumors?\n\n \;\n\nSe lected publications\n\nChander A\, Iacovacci J\, ….\, Bachrach G\, Urban o TG\, Lei M\, Petkar I\, Kong A\, Ng T\, Orlandi E\, Iacovelli NA\, De Ce cco L\, Serafini MS\, Moyes D\, Rancati T\, Ferreira MR. Fusobacterium is toxic for head and neck squamous cell carcinoma and its presence may deter mine a better prognosis. Cancer Commun (Lond). 2024 Aug\;44(8):879-883. do i: 10.1002/cac2.12588\n\nParhi L\, Shhadeh A\, Maalouf N\, Alon-Maimon T\, Scaiewicz V\, Bachrach G. Multiphoton Microscopy of FITC-labelled Fusobac terium nucleatum in a Mouse in vivo Model of Breast Cancer. Bio Protoc. 20 23 Mar 20\;13(6):e4635. doi: 10.21769/BioProtoc.4635.\n\nParhi L\, Alon-Ma imon T\, …\, Mandelboim O\, Granot Z\, Straussman R\, Bachrach G. Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth a nd metastatic progression. Nat Commun. 2020 Jun 26\;11(1):3259. doi: 10.10 38/s41467-020-16967-2.\n\nGur C\, Maalouf N\, Shhadeh A\, Berhani O\, Sing er BB\, Bachrach G\, Mandelboim O. Fusobacterium nucleatum supresses anti- tumor immunity by activating CEACAM1. Oncoimmunology. 2019 Mar 27\;8(6):e1 581531. doi: 10.1080/2162402X.2019.1581531. ATTACH;FMTTYPE=image/jpeg:https://biocityturku.fi/wp-content/uploads/bachr ach400.jpg CATEGORIES:Other events END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20241027T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR