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UID:929@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20260528T130000
DTEND;TZID=Europe/Helsinki:20260528T140000
DTSTAMP:20260527T070534Z
URL:https://biocityturku.fi/events/field-of-view-seminar/
SUMMARY:Field of View Seminar
DESCRIPTION:28th May at 13:00-14:00\nOnsite event\nin auditorium Biologi\, 
 BioCity 2nd floor\n\nDr. Kari Vaahtomeri\, University of Helsinki\nLocaliz
 ed Exocytosis in Control of Guided Cell Migration\n\nWe are pleased to wel
 come Dr Kari Vaahtomeri from the University of Helsinki / Wihuri Research 
 Institute\, where he leads the Lymphatic Endothelial and Leukocyte Guidanc
 e group. Dr Vaahtomeri is also affiliated with the new Centre of Excellenc
 e in Immune–Endothelial Interfaces (IMMENs). His recent work focuses on
  immune cell migration\, lymphatic endothelial guidance cues\, and mechani
 sms controlling leukocyte entry into lymphatic vessels.\n\nCell migration 
 guidance is one of the most complex processes in cell biology. For example
 \, development and immunity are critically dependent on timed and efficien
 t arrival of cells to correct locations. In immunity\, leukocyte’s funct
 ion relies on continuous change of tissue compartments. In this context\, 
 one of the migration events that requires the highest accuracy is the leuk
 ocyte transmigration across the endothelium. Previous studies have shown t
 hat\, for example\, neutrophils prefer to transmigrate the blood endotheli
 al multicellular vertices (i.e. the cell junction where multiple endotheli
 al cells meet). These junctions are characterized by discontinuities in ce
 ll-cell junction proteins and increased ICAM expression\, but it is not kn
 own how leukocytes are guided to these sites. To address this\, we utilize
 d chemokine CCL21-dependent antigen-presenting dendritic cell (DC) entry i
 nto the lymphatic system as a model of guided transmigration.  By using i
 n vivo\, explant and primary cell co-culture assays of cell migration\, to
 gether with advanced imaging methods\, we have identified lymphatic endoth
 elial multicellular vertices as sites of leukocyte entry into the lymphati
 cs. Further\, we show that the entry sites are determined by spatially con
 fined guidance cue exocytosis\, controlling dendritic cell migration to de
 rmal lymphatic vessels. Altogether\, our results exemplify how localized c
 hemokine exocytosis is critical for cell migration guidance cue formation.
ATTACH;FMTTYPE=image/jpeg:https://biocityturku.fi/wp-content/uploads/2023/
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CATEGORIES:Other events
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TZID:Europe/Helsinki
X-LIC-LOCATION:Europe/Helsinki
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DTSTART:20260329T040000
TZOFFSETFROM:+0200
TZOFFSETTO:+0300
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