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UID:560@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20240131T150000
DTEND;TZID=Europe/Helsinki:20240131T160000
DTSTAMP:20240122T080810Z
URL:https://biocityturku.fi/events/fican-seminar-heinaniemi/
SUMMARY:FICAN Seminar: Merja Heinäniemi
DESCRIPTION:January 31st at 15:00\nOnline event\nFlyer\n\nProfessor Merja H
 einäniemi\, Institute of Biomedicine\, School of Medicine\, Faculty of He
 alth Sciences\nCell state transitions and emergence of drug resistance in 
 cancer\n\nWelcome to the 9th FICAN seminar on Wed. 31. 1.2024 at 15.00 –
  16 in Teams. This time the seminar is organized by FICAN East. The semina
 r will be held online and is open to everyone interested in cancer researc
 h.\n\nClick here to join the meeting: JOIN THE MEETING\n\n \n\nGet to kno
 w the speaker\n\nSystems Genomics - Heinäniemi lab\n\nDrug therapy is des
 igned for targeting a specific molecular state in cells. In our ongoing re
 search\, we explore drug therapy in context of the new paradigm that consi
 ders transitions into alternative cell states as a central part in treatme
 nt design for cancer therapy. We have carried out characterization of cell
  states in context of the most common childhood cancer\, acute lymphoblast
 ic leukemia (ALL).\n\nALL represents a paradigmatic example of how alterat
 ions in transcription factors (TFs) initially block the normal development
 al paths. Moreover\, a number of recent studies have shown that cell state
  plasticity presently poses a challenge for treatment success. As TFs repr
 esent the master regulators defining cell states and via their regulatory 
 interactions constrain the space of accessible alternative states\, our fo
 cus has been on abstracting genomics profiles into models of TF activity. 
 More recently\, we have also established analysis methodology to examine m
 icroRNA gene regulation that impacts cellular homeostasis through post-tra
 nscriptional regulation and can thereby play a key role during disease dev
 elopment.\n\nIn my talk\, I will present recent results from our single ce
 ll genomics projects that show how transitions to alternative cell states 
 with aberrant TF activity\, re-wired signaling activity\, stem cell-like p
 roperties\, even a lineage switch\, can underly a poor treatment response 
 in leukemia. Our goal is to chart such transitions to develop new drug tre
 atment strategies that block this route to treatment resistance to avoid d
 isease recurrence (10-15% of patients) that leads to a dramatic increase i
 n cytotoxic burden\, which endangers the life-long health\, development an
 d well-being of children. In broader context of cancer therapy our work co
 ntributes to the conceptual framework of capturing cell state evolution in
 to predictive models to improve design of preventive measures that address
  the prevalent emergence of drug resistance in cancer\n\nEverybody welcome
 !
CATEGORIES:Other events
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TZID:Europe/Helsinki
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