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UID:480@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20190920T140000
DTEND;TZID=Europe/Helsinki:20190920T150000
DTSTAMP:20231013T063548Z
URL:https://biocityturku.fi/events/complifesci-seminar-2/
SUMMARY:CompLifeSci Seminar: Tang\, Siitonen
DESCRIPTION:Dr. Jing Tang\, Faculty of Medicine\, University of Helsinki\nN
 etwork pharmacology approaches for functional precision medicine\n\nDr. Vi
 lja Siitonen\, Department of Biochemistry\, Faculty of Science and Enginee
 ring\,University of Turku\nUnravelling the biosynthesis of antibiotics –
  Nogalamycin as an example\n\n&nbsp\;\n\nCoffee at 13:45\n\n \n\nDr. Tang
  is an assistant professor and group leader at the Faculty of Medicine\, U
 niversity of Helsinki. He received his PhD in statistics from the Universi
 ty of Helsinki in 2019. His main research interests are computational syst
 ems medicine\, aiming at mathematical\, statistical and informatics tools 
 to tackle biomedical questions that may potentially lead to breakthroughs 
 in drug discovery. More info:\n\nhttps://www.helsinki.fi/en/researchgroups
 /network-pharmacology-for-precision-medicine\n\nTwitter: @NETPHARMED\n\nKe
 y publications:\nZagidullin\, B.\, Aldahdooh\, J. Zheng\, S.\, Wang\, W.\,
  Wang\, Y.\, Saad\, J.\, Malyutina\, A.\, Mohieddin\, J.\, Tanoli\, Z.\, P
 essia\, A. and Tang\, J. (2019) DrugComb - an integrative cancer drug comb
 ination data portal. Nucleic Acids Res. pii: gkz337. doi: 10.1093/nar/gkz3
 37 \n\nMalyutina\, A.\, Majumder\, M.M.\, Wang\, W.\, Pessia\, A.\, Heckm
 an\, C. and Tang\, J. (2019) Drug combination sensitivity scoring facilita
 tes the discovery of synergistic and efficacious drug combinations in canc
 er. PLoS Comput. Biol. 15(5):e1006752.\n\nIanevski A.\, He L.\, Aittokalli
 o T. and Tang J. (2017) SynergyFinder: a web application for analyzing dru
 g combination dose-response matrix data. Bioinformatics. 33\, 2413-2415\n\
 nYadav B.\, Wenerberg K.\, Aittokallio T. and Tang J. (2015) Searching for
  drug synergy in complex dose-response landscapes using an interaction pot
 ency model. Comput. Struct. Biotechnol. J. 13\, 504-13\n\nTang J. and Aitt
 okallio T. (2014). Network pharmacology strategies toward multi-target ant
 icancer therapies: from computational models to experimental design princi
 ples. Curr. Pharm. Des. 20\, 23-36\n\n \n\nDr. Vilja Siitonen graduated a
 s PhD in 2016 from the Department of Biochemistry at the University of Tur
 ku in the “Antibiotic Biosynthetic Engineering"\, ABE. During her PhD Vi
 lja studied biosynthesis of the anthracycline antibiotic nogalamycin produ
 ced by Streptomyces nogalater. She found genes responsible for the late st
 age of the nogalamycin biosynthesis and characterized enzymes and low mole
 cular weight intermediates from the nogalamycin biosynthesis pathway. Afte
 r her PhD Vilja has been studying bioactive compounds from several Strepto
 myces strains employing a wide repertoire of methods including high resolu
 tion mass\, high-performance liquid chromatography and nuclear magnetic re
 sonance. Her main interest is to understand how antibiotics are built and 
 to find novel bioactive compounds.\n\nKey publications:\nSiitonen\, V.\, N
 ji Wandi\, B.\, Törmanen\, A. and Metsä-Ketelä\, M. (2018) Enzymatic Sy
 nthesis of the C-glycosidic Moiety of Nogalamycin R. ACS Chem. Biol. 13(9)
 : 2433–2437\n\nSiitonen\, V.\, Selvaraj\, B.\, Niiranen\, L.\, Lindqvist
 \, Y.\, Schneider\, G.\, and Metsä-Ketelä\, M. (2016) Divergent Non-heme
  Iron Enzymes in the Nogalamycin Biosynthetic Pathway. Proc. Natl. Acad. S
 ci. U. S. A.\,113(19):5251–5256 \n\nClaesson\, M.\, Siitonen\, V.\, Dob
 ritzsch\, D.\, Metsä-Ketelä\, M.\, and Schneider\, G. (2012) Crystal str
 ucture of the glycosyltransferase SnogD from the biosynthetic pathway of n
 ogalamycin in Streptomyces nogalater. FEBS journal\, 279(17): 3251–3263.
  \n\nSiitonen\, V.\, Blauenburg\, B.\, Kallio\, P.\, Mäntsälä\, P.\, a
 nd Metsä-Ketelä\, M. (2012) Discovery of a Two-Component Monooxygenase S
 noaW/SnoaL2 Involved in Nogalamycin Biosynthesis. Chemistry &amp\; Biology
 \, 19(5): 638–646. \n\nSiitonen\, V.\, Claesson\, M.\, Patrikainen\, P.
 \, Aromaa\, M.\, Mäntsälä\, P.\, Schneider\, G.\, and Metsä-Ketelä\, 
 M. (2012) Identification of late-stage glycosylation steps in the biosynth
 etic pathway of the anthracycline nogalamycin. ChemBioChem\, 13(1): 120–
 128.\n\n&nbsp\;
CATEGORIES:BiocityTurku events
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DTSTART:20190331T040000
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