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UID:70@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20230509T130000
DTEND;TZID=Europe/Helsinki:20230509T140000
DTSTAMP:20231013T065541Z
URL:https://biocityturku.fi/events/cellmech-cellcom-seminar/
SUMMARY:CellMech CellCom Seminar
DESCRIPTION:9th May at 13:00\nOn-site event\nAuditorium Biochemistry (Bioci
 ty 3rd Floor)\n\nBen Goult\, University of Kent\, UK\nTALIN in MECHANOmemo
 ry – spatial organisation encoded by BINary mechanochemical switches\n\n
  \n\nDr. Goult is recognized for defining the protein talin as a major me
 chanosensitive signaling hub\, and more recently discovered that talin has
  “molecular memory” providing organisms with the capability to store d
 ata through persistent alterations in protein conformation.\n\nTalin\, the
  primary link between integrins and the actin cytoskeleton\, coordinates t
 he binding of a wide range of cytoskeletal and signaling adaptors in a for
 ce-dependent manner. Our foundational work on talin has shown that mechano
 sensitive proteins contain force-dependent switches and can store binary i
 nformation persistently\, which can be written/updated using small changes
  in mechanical force. Talin contains 13 of these binary switches\, and the
 y mediate the linkage between integrin and actin filaments inside the cell
  to transmit mechanical loads and enable talin to serve as a mechanosensit
 ive signaling hub for the recruitment of many other proteins. Talin\, in c
 onjunction with vinculin\, forms a meshwork of these switches to form a me
 shwork code\, or more concisely\, a MeshCODE. I propose that the multiple 
 switches within the talin rod function to process and store time- and forc
 e-dependent mechanical and chemical information. Here Ben will talk about 
 the ability to write/store/compute information in the shape of these talin
  molecules and present new data on the role of post-translational modifica
 tions. Most strikingly\, our new data on the changing shape of a talin mol
 ecule as its pattern of switches unfold and refold indicates a spatial rea
 rrangement of molecules within integrin adhesion sites. A switch-changing 
 state introduces a quantized step-change in length (40\, 50\, or 150 nm de
 pending on the switch)\, which results in precise repositioning of ligands
 \, and a molecule attached to a talin can relocate up to 700 nm as a funct
 ion of these switch patterns whilst still being coupled to the integrin. V
 isualizing talin to scale offers a radically new perspective of what binar
 y information in a cell looks like and indicates a mechanism for how alter
 ations in the binary strings of talin molecules lead to persistent changes
  in signaling and adhesion architecture.\n\n&nbsp\;\n\nSelected publicatio
 ns\n\nSam Barnett and Ben Goult. (2022) The MeshCODE to scale – Visualis
 ing synaptic binary information. Frontiers in Cellular Neuroscience. 16:10
 14629 PMID: 36467609\n\nGoult BT\, Brown NH and Schwartz M. (2021) Talin i
 n mechanotransduction and mechanomemory at a glance. J. Cell Sci. 134(20):
 jcs258749 PMID: 34708856\n\nGoult BT (2021) The mechanical basis of memory
  – the MeshCODE theory. Frontiers in Molecular Neuroscience 14:592951 PM
 ID: 3371664
CATEGORIES:BiocityTurku events
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