BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.3.3//EN BEGIN:VEVENT UID:938@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20260820T000000 DTEND;TZID=Europe/Helsinki:20260820T013000 DTSTAMP:20260616T120831Z URL:https://biocityturku.fi/events/biocity-turku-guest-seminar-sasaki-and- senda/ SUMMARY:BioCity Turku Guest Seminar: Sasaki and Senda DESCRIPTION:20th August at 12:00-13:30\nOnsite event\nin Presidentti audito rium\, BioCity\n\nCoffee and sandwich at 11:45\n\nProf. Atsuo T. Sasaki\, University of Cincinnati College of Medicine\, USA\nDecoding GTP energy me tabolism: insights into molecular oncogenesis and immunotherapy\n\nand\n\n Prof. Toshiya Senda\, High Energy Accelerator Research Organization (KEK)\ , Structural Biology Research Center\, Japan\nCrossroads of Cell Biology a nd Structural Biology: How Structural Biology Contributes to GTP Metabolis m Studies\n\nHost: Kari Kopra (kari.kopra@utu.fi)\n\n \;\n\nAtsuo T. S asaki is Professor of Medicine at the University of Cincinnati College of Medicine and Project Professor at Keio University’s Institute for Advanc ed Biosciences. His research focuses on GTP energy metabolism at the inter face of signaling\, growth control\, cancer biology\, and therapeutic deve lopment. His laboratory discovered the mammalian GTP sensor PI5P4Kβ and g lioma GTP metabolic rewiring that supports ribosome biogenesis and prolife ration. His group now develops GTP-GEEKS approaches to understand and targ et GTP-dependent biological programs. He is a 2022 Human Frontier Science Program Program Grant awardee.\n\nToshiya Senda is a Professor\, Head of S ynchrotron Radiation Science Division II\, and Director of the Structural Biology Research Center at the Institute of Materials Structure Science\, KEK. He employs multidisciplinary approaches to study histone chaperones\, pathogenic signaling by Helicobacter pylori\, and the catalytic mechanism s of redox enzymes. Over the past decade\, as a member of the "GTP Geeks\, " he has focused on the structural biology aspects of GTP metabolism.\n\n& nbsp\;\n\nSelected publications\n\nMatsugaki N\, Senda T. Advances in macr omolecular crystallography at the Photon Factory: automation from crystall ization to structural determination. J Synchrotron Radiat. 2025\, 32\, 567 -576. doi:10.1107/S1600577525001407\n\nOgawa-Iio\, Takeuchi K\, Shigemi K\ , …\, Hashizume R\, Osuka S\, Goyama S\, Yasuda T\, Senda T\, Sasaki AT IMPDH and GTP metabolism in cancer: Mechanisms\, regulation\, and translat ional scope. Cancer Sci. 2025\, 116\, 3250-3265. doi:10.1111/cas.70200\n\n Takeuchi K\, Senda M\, Ikeda Y\, Okuwaki K\, Fukuzawa K\, Nakagawa S\, Sas aki M\, Sasaki AT\, Senda T. Functional molecular evolution of a GTP sensi ng kinase: PI5P4Kβ. FEBS J. 2023\, 290\, 4419-4428. doi:10.1111/febs.1676 3\n\nTakeuchi K\, Ikeda Y\, Senda M\, …\, Fujii Y\, Sasaki AT\, Senda T. The GTP responsiveness of PI5P4Kβ evolved from a compromised trade-off b etween activity and specificity. Structure. 2022\, 30\, 886-899. doi:10.10 16/j.str.2022.04.004\n\nKofuji S\, Hirayama A\, …\, Wakimoto H\, Holland EC\, Yong WH\, Horbinski C\, Nakano I\, DeBerardinis RJ\, Bachoo RM\, Mis chel PS\, Yasui W\, Suematsu M\, Saya H\, Soga T\, Grummt I\, Bierhoff H\, Sasaki AT. IMP dehydrogenase-2 drives aberrant nucleolar activity and pro motes tumorigenesis in glioblastoma. Nat Cell Biol. 2019 Aug\;21(8):1003-1 014. doi: 10.1038/s41556-019-0363-9. ATTACH;FMTTYPE=image/jpeg:https://biocityturku.fi/wp-content/uploads/sasak isenda.jpg CATEGORIES:BiocityTurku events END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20260329T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR