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UID:576@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20240301T090000
DTEND;TZID=Europe/Helsinki:20240301T100000
DTSTAMP:20240228T103937Z
URL:https://biocityturku.fi/events/biocity-turku-guest-seminar-prof-paul-b
 rennan/
SUMMARY:BioCity Turku Guest Seminar: Prof. Paul Brennan
DESCRIPTION:March 1st at 09:00\nOn-site event\nPresidentti auditorium\, Bio
 City\n\n \n\nProf. Paul Brennan\, University of Oxford\, UK\nTarget disco
 very for rare diseases with epigenetic chemical probes\n\nHost: Kari Kopra
  (kari.kopra@utu.fi)\n\nCoffee and sandwiches served at 08:45\n\n&nbsp\;\n
 \nhttps://www.brennanresearchgroup.com/paul-brennan\n\nChemical probes are
  potent and selective small molecule inhibitors that can be used in cellul
 ar assays to induce a phenotype.  Screening a library of epigenetic chemi
 cal probes in cellular assays from patient tissue\, we have discovered nov
 el targets and lead compounds for developing treatments for two rare disea
 ses.  The first CREBBP/EP300 bromodomain chemical probe SGC-CBP30 was sho
 wn to inhibit myofibroblast nodule formation in cells form Dupuytren's con
 tracture patients.  A-196\, a selective inhibitor of the H4K20me2 and me3
  methyltransferases KMT5B/C increased expression of the critical mitochond
 rial factor frataxin in a HEK-293 and patient fibroblast derived models of
  Friedreich’s ataxia.  A-196 analogues are currently being developed as
  in vivo chemical probes to be tested in pre-clinical models of Friedreich
 ’s ataxia.\n\n&nbsp\;\n\nSelected publications\n\nN Frank\, J Nugent\, B
 R Shire\, HD Pickford\, P Rabe\, AJ Sterling\, ... 202. Synthesis of meta-
 substituted arene bioisosteres from [3.1.1]propellane. Nature 611 (7937)\,
  721-726\n\nMJW Sim\, Z Stotz\, J Lu\, P Brennan\, EO Long\, PD Sun. 2023.
  T cells discriminate between groups C1 and C2 HLA-C. Elife 11\, e75670\n\
 nS Müller\, S Ackloo\, A Al Chawaf\, B Al-Lazikani\, A Antolin\, JB Baell
 \, ... 2022. Target 2035–update on the quest for a probe for every prote
 in. RSC Medicinal Chemistry 13 (1)\, 13-21\n\nL Nie\, TC Pascoa\, ACW Pike
 \, SR Bushell\, A Quigley\, GF Ruda\, A Chu\, ... 2021. The structural bas
 is of fatty acid elongation by the ELOVL elongases. Nature structural &amp
 \; molecular biology 28 (6)\, 512-520\n\nJL Gray\, F von Delft\, PE Brenna
 n. 2020. Targeting the small GTPase superfamily through their regulatory p
 roteins. Angewandte Chemie International Edition 59 (16)\, 6342-6366\n\n&n
 bsp\;
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CATEGORIES:BiocityTurku events
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