BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN BEGIN:VEVENT UID:793@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20251021T120000 DTEND;TZID=Europe/Helsinki:20251021T130000 DTSTAMP:20250929T072615Z URL:https://biocityturku.fi/events/biocity-turku-guest-seminar-prof-mark-d aly/ SUMMARY:BioCity Turku Guest Seminar: Prof. Mark Daly DESCRIPTION:21st October at 12:00-13:00\nOnsite event\nin Presidentti audit orium\, BioCity\n\nProf. Mark Daly\, Massachusetts General Hospital\; Harv ard Medical School\, USA\nFinnGen and the road ahead in human genetics\n\n Host: Teemu Niiranen (tejuni@uti.fi)\n\nCoffee and sandwich for the first 40 to come on-site at 11:45!\n\n \;\n\nMark Daly is the founding Chief of the Analytic and Translational Genetics Unit (ATGU) at Massachusetts G eneral Hospital and Assistant Professor at the Harvard Medical School. His research has historically focused on the development and application of s tatistical methods for the discovery and interpretation of genetic variati on responsible for complex human disease\, and with the creation of the AT GU\, he and other core faculty are focused on the interpretation of genome sequence and the use of genome information in clinical settings. Mark is also an institute member and co-director of the Program in Medical and Pop ulation Genetics at the Broad Institute of MIT and Harvard\, where he lead s many large-scale genome sequencing studies in autism and inflammatory bo wel disease.\n\nMark was appointed Director of the Institute for Molecular Medicine Finland (FIMM) at the University of Helsinki from February of 20 18 through April 2023 while maintaining his lab in Boston. He has returned to Boston and maintains an affiliate position at Institute for Molecular Medicine Finland. FIMM is a translational research institute focusing on c ancer\, digital diagnostics\, genetics\, and epidemiology and is home to l andmark efforts such as the FinnGen Project.\n\nWhile developing computati onal and statistical methods that can be broadly applied\, his group has s everal primary medical genetics research foci. He has an extensive researc h program in neuropsychiatric genetics - particularly in autism\, schizoph renia\, and ADHD – and has led large-scale GWAS and exome sequencing eff orts in this area. His lab and Dr. Ben Neale's lab serve as an analytic hu b for the Psychiatric GWAS Consortium\, an international consortium leadin g the largest collaborative GWAS studies in 5 major psychiatric disorders. He also has a longstanding effort in the mapping of genes for Crohn’s d isease and ulcerative colitis\, where he helped found and lead an internat ional effort that has identified more than 150 genetic risk factors and\, in collaboration with Dr. Ramnik Xavier’s group\, pursues the functional interpretation and clinical ramifications of these continued gene discove ry efforts. Along with Dr. Rehm\, he is co-PI of the gnomAD project and is committed to ensuring the output of all ATGU genomic research is maximall y accessible and useful to the clinical and research communities.\n\nMark received his B.S. in physics from MIT and his Ph.D. in human genetics from Leiden University\, Netherlands.\n\n \;\n\nSelected recent publicatio ns\n\nRare genetic variation in PTPRB is associated with central serous ch orioretinopathy\, varicose veins and glaucoma. Rämö JT\, Gorman BR\, ... \, Palotie A\, Peachey NS\, Turunen JA\, Boon CJ\, Ellinor PT\, Iyengar S K\, Daly MJ\, Rossin EJ. Nat Commun. 2025 May 3\;16(1):4127\n\nGenome-wide association study reveals mechanisms underlying dilated cardiomyopathy an d myocardial resilience. Jurgens SJ\, Rämö JT\, ...\, Palotie A\, Amin A S\, Charron P\, Meder B\, Ellinor PT\, Daly M\, Aragam KG\, Bezzina CR. Na t Genet. 2024 Dec\;56(12):2636-2645\n\nPolygenic risk scores as a marker f or epilepsy risk across lifetime and after unspecified seizure events. Hey ne HO\, Pajuste FD\, Wanner J\, Daniel Onwuchekwa JI\, Mägi R\, Palotie A \; FinnGen\; Estonian Biobank research team\; Kälviainen R\, Daly MJ. Nat Commun. 2024 Jul 25\;15(1):6277\n\nPublic platform with 39\,472 exome con trol samples enables association studies without genotype sharing. Artomov M\, Loboda AA\, Artyomov MN\, Daly MJ. Nat Genet. 2024 Feb\;56(2):327-335 ATTACH;FMTTYPE=image/jpeg:https://biocityturku.fi/wp-content/uploads/daly- 400px.jpg CATEGORIES:BiocityTurku events END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20250330T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR