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UID:175@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20190315T091500
DTEND;TZID=Europe/Helsinki:20190315T100000
DTSTAMP:20231013T060739Z
URL:https://biocityturku.fi/events/biocity-guest-seminar-prof-benedikt-kes
 sler/
SUMMARY:BioCity Guest Seminar: Prof. Benedikt Kessler
DESCRIPTION:Prof. Benedikt Kessler\, University of Oxford\nTargeting p53 an
 d Myc via deubiquitinases\n\nHost: Kari Kopra (khkopr@utu.fi)\n\nCoffee/te
 a and sandwiches served at 9:00\n\n&nbsp\;\n\nBenedikt Kessler graduated f
 rom the Swiss Federal Institute of Technology ETH in Zurich\, Switzerland 
 in biochemistry in 1992. He received his PhD in immunology at the Ludwig I
 nstitute for Cancer Research at the University of Lausanne in 1998. He the
 n joined the laboratory of Hidde L. Ploegh at the Pathology Department at 
 Harvard Medical School in Boston\, USA\, to study the role of proteolysis 
 in antigen processing and presentation. After three years\, he established
  a research platform in proteomics at Harvard Medical School. Currently he
  has nearly 300 publications and he is Professor of Biochemistry and Life 
 Science Mass Spectrometry at the Target Discovery Institute (TDI)\, Depart
 ment of Medicine\, University of Oxford\, UK. His laboratory is focused on
  ubiquitin and protease biology with a specialty in mass spectrometry\, pr
 oteomics and recently in metabolomics. Expertise in his laboratory is also
  used to understand disease processes in translational research.\n\nSelect
 ed recent publications\nNishi R\, Wijnhoven PWG\, Kimura Y\, Matsui M\, Ko
 nietzny R\, Wu Q\, Nakamura K\, Blundell TL\, Kessler BM. 2018. The deubiq
 uitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage. S
 ci Rep\, 8 (1)\, pp. 17891.\n\nTurnbull AP\, Ioannidis S\, Krajewski WW\, 
 Pinto-Fernandez A\, Heride C\, Martin ACL\, Tonkin LM\, Townsend EC\, Buke
 r SM\, Lancia DR et al. 2017. Molecular basis of USP7 inhibition by select
 ive small-molecule inhibitors. Nature\, 550 (7677)\, pp. 481-486.\n\nPinto
 -Fernandez A\, Kessler BM. 2016. DUBbing Cancer: Deubiquitylating Enzymes 
 Involved in Epigenetics\, DNA Damage and the Cell Cycle As Therapeutic Tar
 gets. Front Genet\, 7 (JUL)\, pp. 133.\n\n&nbsp\;
CATEGORIES:BiocityTurku events
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